Last edited by Tojas
Saturday, July 25, 2020 | History

6 edition of Ion Channels and Disease found in the catalog.

Ion Channels and Disease

Channelopathies

by Frances M. Ashcroft

  • 23 Want to read
  • 13 Currently reading

Published by Academic Press .
Written in English

    Subjects:
  • Biomedical engineering,
  • Biophysics,
  • Cellular biology,
  • Neurosciences,
  • Science/Mathematics,
  • Medical / Nursing,
  • Cell Physiology,
  • Membrane Biochemistry,
  • Science,
  • Pathology, Molecular,
  • Biochemistry,
  • Life Sciences - Cytology,
  • Pathology,
  • Science / Biology,
  • Ion channels,
  • Life Sciences - Biochemistry,
  • Life Sciences - Biophysics

  • The Physical Object
    FormatHardcover
    Number of Pages481
    ID Numbers
    Open LibraryOL9280178M
    ISBN 100120653109
    ISBN 109780120653102

      Ion channels play important roles in vital cellular signaling processes in both excitable and nonexcitable cells. Since , a large number of channel genes have been cloned, and their biophysical properties, subunit stoichiometries, channel assemblies, and modulation by second messengers and ligands have been gradually elucidated. At present, more than ten ion channel genes have been Cited by: Select the correct description of the voltage-gated ion channels for a region of sarcolemma that is undergoing depolarization. a. Sodium and potassium channels are both open Which of the following is an autoimmune disease that destroys ACh receptors? a. myotonic dystrophy for example picking up a book? a. Concentric isotonic contraction.

    The aim of this issue on Ion Channels and Disease is to briefly describe the historical development of the protein ion channel concept, the measurements used to determine how channels work at the molecular level, some consequences of their failure, and how channels (or biomimetic analogues of them) might prove useful in diagnosing and/or managing by: Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes.

      Ion channels allow the movement of ions across cell membranes, and therefore fundamental physiological processes such as muscle contraction. In , . Ion channels are specific for calcium (Ca+2), sodium(Na+), potassium(K+) or chloride(Cl'). A cell membrane may have a quite few thousand ion channels particular for each of these ions. The following disorders result from abnormal ion channels: Cystic Fibrosis and Chloride Channels - it is an inherited illness distinguished by the build up of.


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Ion Channels and Disease by Frances M. Ashcroft Download PDF EPUB FB2

Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies.

Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, Ion Channels and Disease book publication includes cross-referencing for disease, channels, and tissues.

Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study by:   Furthermore, ion channels mutated in human disease may be excellent targets for drug intervention—often in patients which do not carry a mutation in the respective gene.

An excellent example is the identification (21, 22, 51) of the KCNQ2 and KCNQ3 K + channel subunits as the genes underlying a rare human neonatal epilepsy, by: The amino acid sequences of many different ion channel proteins have been determined, and in a few cases the X-ray crystal structure of the channel is known as well.

Based on their structure, the majority of ion channels can be classified into six or seven superfamilies. For potassium-selective channels, which are among the best-characterized ion channels, four homologous transmembrane.

Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of Cited by: There are many diseases related to ion channels.

Mutations in muscle voltage-gated sodium, potassium, calcium and chloride channels, and acetylcholine-gated channel may lead to such physiological disorders as hyper- and hypokalemic periodic paralysis, myotonias, long QT syndrome, Brugada syndrome, malignant hyperthermia and by: Ion channels participate in the excitation-restoration of neurons and myocytes.

Mutations of ion channels in these cells cause abnormal excitation and diseases such as long QT syndrome and ataxia. The publication in of Bertil Hille’s Ionic Channels in Excitable Membranes (Hille, ) marked a milestone and turning point in the field of ion channel biophysics and only did it provide a scholarly, comprehensive, and clearly written summary of the historical and conceptual framework of the field, it provided an essential introduction for beginners, including Cited by: 1.

There are many diseases related to ion channels. Mutations in muscle voltage-gated sodium, potassium, calcium and chloride channels, and acetylcholine-gated channel may lead to such physiological. Channelopathies are diseases caused by disturbed function of ion channel subunits or the proteins that regulate them.

These diseases may be either congenital (often resulting from a mutation or mutations in the encoding genes) or acquired (often resulting from autoimmune attack on an ion channel).

There are many distinct dysfunctions known to be caused by ion channel cations: Dependent on type. Include: Sudden death.

The Symposium of the Society of General Physiologists, Ion Channels, and Genetic Diseases, held September, at the Marine Biological Laboratory in Woods Hole, Massachusetts, brought together scientists representing the broad spectrum of disciplines that have converged to produce our current understanding of the role of ion channel gene mutations in inherited disorders.

Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent processes is often involved, either as the cause or effect of the illness.

Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and. Ion channels constitute a class of proteins that is ultimately responsible for generating and orchestrating the electrical signals passing through the thinking brain, the beating heart, and the con Cited by: Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease.

Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases.

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters.

It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The. This book discusses voltage-gated ion channels and their importance in drug discovery and development.

The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment.

Ion channel: A protein that acts as a pore in a cell membrane and permits the selective passage of ions (such as potassium ions, sodium ions, and calcium ions), by means of which electrical current passes in and out of the cell. Ion channels also serve many other critically important functions including chemical signalling, transcellular transport, regulation of pH, and regulation of cell volume.

Ion Channels: A Laboratory Manual it is a useful resource for all cell biologists and neuroscientists seeking to further understand the complex roles of ion channels in physiology and disease. Contents CHAPTER 1 Ion Channels: History, Diversity, and Impact “The book is an extremely useful guide for the study of ion channels.

The elucidation of many human ion-channel diseases, 'channelopathies', and the disruption of genes that encode ion channels in mice provide fascinating insights into Cited by:. ION CHANNELS I. Basic biophysical properties of ion channels II.

Structure and Function III. Regulation by Subunits and Enzymes IV. Physiological functions of ion channels V. Ion Channels and Disease VI. Ion Channels as Targets for Drugs Book references: Important slides:! Drugs Targetting Ion Channels Ion Channels are varied widely and play a wide range of critical biological functions.

55 different medical conditions have been attributed to ion channel dysfunction. Owing to these conditions, % of all drugs are targetted to ion channels (second highest after GPCRs). Worldwide sale of ion channel drugs.ion channel disease A group of diseases marked clinically by muscular weakness, absent muscle tone, or episodic muscular paralysis.

The diseases are caused by congenital defects in the cell membrane proteins that move ions into and out of the cell.